Shotgun proteomics of cyanobacteria—applications of experimental and data-mining techniques
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چکیده
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15 صفحه اولComputational analysis of shotgun proteomics data.
Proteomics technology is progressing at an incredible rate. The latest generation of tandem mass spectrometers can now acquire tens of thousands of fragmentation spectra in a matter of hours. Furthermore, quantitative proteomics methods have been developed that incorporate a stable isotope-labeled internal standard for every peptide within a complex protein mixture for the measurement of relati...
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چکیده ندارد.
15 صفحه اولHierarchical clustering of shotgun proteomics data.
A new result report for Mascot search results is described. A greedy set cover algorithm is used to create a minimal set of proteins, which is then grouped into families on the basis of shared peptide matches. Protein families with multiple members are represented by dendrograms, generated by hierarchical clustering using the score of the nonshared peptide matches as a distance metric. The pept...
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ژورنال
عنوان ژورنال: Briefings in Functional Genomics
سال: 2006
ISSN: 2041-2657,2041-2649
DOI: 10.1093/bfgp/ell021